GenomicRisk AI

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38.0% riskMODERATE

Patient Beta

3 genes analyzed · 2 SNPs · 5 epistasis pairs

TCF7L2FTOPPARG

SHAP Waterfall

feature attribution breakdown
TCF7L2
↑ TCF7L2 pushed risk +0.19
+0.187
FTO
↑ FTO pushed risk +0.12
+0.121
SLC30A8
↑ SLC30A8 pushed risk +0.10
+0.099
PPARG
↓ PPARG reduced risk -0.08
-0.083
KCNJ11
↑ KCNJ11 pushed risk +0.07
+0.066
MTNR1B
↑ MTNR1B pushed risk +0.06
+0.061
CDKAL1
↑ CDKAL1 pushed risk +0.05
+0.050
IGF2BP2
↑ IGF2BP2 pushed risk +0.04
+0.039
CDKN2A/B
↑ CDKN2A/B pushed risk +0.03
+0.028
HHEX
↓ HHEX reduced risk -0.02
-0.022
Final Score
38.0%

SHAP Beeswarm

Low feature value
High feature value
TCF7L2FTOSLC30A8PPARGKCNJ11CDKAL1IGF2BP2CDKN2A/BHHEXMTNR1BSHAP value (impact on model output)-0.50-0.250.000.250.50

Gene Biological Mapping

annotated by our research team
TCF7L2+0.187

Strongest T2DM risk locus — impairs insulin secretion via WNT pathway disruption

WNT signaling / beta-cell function
FTO+0.121

Obesity-linked locus — increases BMI through altered appetite regulation

Energy homeostasis / adipogenesis
SLC30A8+0.099

Zinc transporter in beta-cells — affects insulin crystallization and storage

Zinc transport / insulin granules
PPARG-0.083

Nuclear receptor — protective alleles improve insulin sensitivity in adipose tissue

Lipid metabolism / insulin sensitivity
KCNJ11+0.066

Potassium channel subunit — risk alleles cause beta-cell depolarization defects

ATP-sensitive K+ channel
CDKAL1+0.050

Modifies tRNA for proinsulin translation — affects insulin processing fidelity

tRNA modification / proinsulin processing
IGF2BP2+0.039

RNA-binding protein — risk variants reduce beta-cell mass maintenance

mRNA stability / beta-cell proliferation
CDKN2A/B+0.028

Cell cycle inhibitors — risk alleles accelerate beta-cell aging and apoptosis

Cell cycle regulation / senescence
HHEX-0.022

Homeobox transcription factor — essential for normal pancreatic organogenesis

Pancreas development

Epistasis Interaction Matrix

click a cell to see interaction details
TCF7L2
FTO
PPARG
TCF7L2
—
0.76
FTO
0.76
—
0.58
PPARG
0.58
—

Variant Suggestions

epistasis-aware allele recommendations
TCF7L2Pathogenic
-31% risk
CURRENT ALLELE

rs7903146_T

SAFER ALLELE

rs7903146_C

⚡ Combined with FTO rs9939609 A→T, interaction score drops 0.76 → 0.43

FTORisk factor
-18% risk
CURRENT ALLELE

rs9939609_A

SAFER ALLELE

rs9939609_T

⚡ Reduces adipogenesis-WNT crosstalk with TCF7L2

SLC30A8Protective
-14% risk
CURRENT ALLELE

rs13266634_C

SAFER ALLELE

rs13266634_T

⚡ T allele is actually protective — loss of function reduces T2DM risk