GenomicRisk AI

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15.0% riskLOW

Patient Gamma

2 genes analyzed · 0 SNPs · 2 epistasis pairs

PPARGHHEX

SHAP Waterfall

feature attribution breakdown
TCF7L2
↑ TCF7L2 pushed risk +0.07
+0.068
FTO
↑ FTO pushed risk +0.04
+0.044
SLC30A8
↑ SLC30A8 pushed risk +0.04
+0.036
PPARG
↓ PPARG reduced risk -0.03
-0.030
KCNJ11
↑ KCNJ11 pushed risk +0.02
+0.024
MTNR1B
↑ MTNR1B pushed risk +0.02
+0.022
CDKAL1
↑ CDKAL1 pushed risk +0.02
+0.018
IGF2BP2
↑ IGF2BP2 pushed risk +0.01
+0.014
CDKN2A/B
↑ CDKN2A/B pushed risk +0.01
+0.010
HHEX
↓ HHEX reduced risk -0.01
-0.008
Final Score
15.0%

SHAP Beeswarm

Low feature value
High feature value
TCF7L2FTOSLC30A8PPARGKCNJ11CDKAL1IGF2BP2CDKN2A/BHHEXMTNR1BSHAP value (impact on model output)-0.50-0.250.000.250.50

Gene Biological Mapping

annotated by our research team
TCF7L2+0.068

Strongest T2DM risk locus — impairs insulin secretion via WNT pathway disruption

WNT signaling / beta-cell function
FTO+0.044

Obesity-linked locus — increases BMI through altered appetite regulation

Energy homeostasis / adipogenesis
SLC30A8+0.036

Zinc transporter in beta-cells — affects insulin crystallization and storage

Zinc transport / insulin granules
PPARG-0.030

Nuclear receptor — protective alleles improve insulin sensitivity in adipose tissue

Lipid metabolism / insulin sensitivity
KCNJ11+0.024

Potassium channel subunit — risk alleles cause beta-cell depolarization defects

ATP-sensitive K+ channel
CDKAL1+0.018

Modifies tRNA for proinsulin translation — affects insulin processing fidelity

tRNA modification / proinsulin processing
IGF2BP2+0.014

RNA-binding protein — risk variants reduce beta-cell mass maintenance

mRNA stability / beta-cell proliferation
CDKN2A/B+0.010

Cell cycle inhibitors — risk alleles accelerate beta-cell aging and apoptosis

Cell cycle regulation / senescence
HHEX-0.008

Homeobox transcription factor — essential for normal pancreatic organogenesis

Pancreas development

Epistasis Interaction Matrix

click a cell to see interaction details
PPARG
HHEX
PPARG
—
HHEX
—

Variant Suggestions

epistasis-aware allele recommendations
TCF7L2Pathogenic
-31% risk
CURRENT ALLELE

rs7903146_T

SAFER ALLELE

rs7903146_C

⚡ Combined with FTO rs9939609 A→T, interaction score drops 0.76 → 0.43